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KMID : 0602820100160010039
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Korean Journal of Bronchoesophagology
2010 Volume.16 No. 1 p.39 ~ p.46
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The Significance of c-Met and Ki-67 Expression in the Head and Neck Squamous Cell Carcinoma
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Kim Jun
Choi Ji-Yun
Lim Sung-Chul
Do Nam-Yong
Park Jun-Hee
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Abstract
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Purpose:Various tumor markers have been studied in an attempt to evaluate and decide the optimal treatment of the patients with head and neek squamous cell carcinoma (HNSCC). A nuclear antigen Ki-67 is a proliferative marker of tumor cells in all phases of cell cycle except G0. c-met gene, the tyrosine kinase receptor for hepatocyte growth tactor, may play various roles in malignant transformation. The authors evaluated the prognostic significance of Ki-67 and c-Met in surgical specimens of HNSCC to determine the relationship with the various clinicopathological characteristics.
Methods:Formatin-fixed paraffin-embedded surgical specimens were obtained from 54 patients with HNSCC. Ki-67 and c-Met expressions were analyzed by immunohistochemical staning and were compared with the clinicopathological characteristics such as, pathologic differentiation, tumor stage, clinical stage and lymph node metastasis.
Results:Ki-67 and c-Met over-expression was detected in 66.7% and 90.7% in HNSCC. There was positive correlation of increased expression of Ki-67 with tumor stage. and clinical stage, increased expression of e-Met with tumor stage, clinical stage, and nodal status. The expression of c-Met had a significant positive relationship with Ki-67 index (p<0.05).
Conclusions: Therefore, Ki-67 and c-Met are useful markers of tumor progression, aggressiveness and prognosis in HNSCC.
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KEYWORD
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c-Met, Ki-67, Head and neck squamous cell carcinoma, Prognosis
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